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KMID : 1023120130110020275
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Korean Journal of Aesthetic Society
2013 Volume.11 No. 2 p.275 ~ p.280
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Tyrosinase Inhibitory Activity and Melanin Production Inhibitory Activity of the Methanol Extract and Fractions from Dendropanax morbifera Lev.
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Mo Jeong-Hee
Oh Su-Jeong
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Abstract
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This study investigated tyrosinase inhibitory and melanin production inhibitory activity of methanol extract and fractions from Dendropanax morbifera Lev. to examine its activation for skin whitening and discovered that ethyl acetate and n-butanol fractions had high capacity of tyrosinase inhibitory. Also, as a result of measuring melanin production inhibitory in B16F10 cells which were stimulated by α-MSH, it was discovered that ethyl acetate fractions within the range of concentration without cytotoxicity had higher repression effects. As ethyl acetate fractions had higher flavonoid contents and DPPH radical absorption capacity than those of other specimens and the ethyl acetate fractions in methanol extracts from Dendropanax morbifera Lev. had excellence in anti-oxidation, tyrosinase inhibitory, and melanin production inhibitory activity, this study suggested that they have potential as a functional material of skin whitening cosmetics.
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KEYWORD
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D endropanax morbifera Lev., Tyrosinase, Melanin, Whitening
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